5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid
Names
[ CAS No. ]:
1225146-53-1
[ Name ]:
5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid
[Synonym ]:
Bz-Tz-acid
Chemical & Physical Properties
[ Melting Point ]:
163-170°C (decomposition)
[ Molecular Formula ]:
C14H15N5O3
[ Molecular Weight ]:
301.3
[ Storage condition ]:
-20°C
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-36-37-38
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Bioconjug. Chem. 22 , 2263-2270, (2011)
1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa...
Tetrazine-based cycloadditions: application to pretargeted live cell imaging.Bioconjug. Chem. 19 , 2297-2299, (2008)
Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T...
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.J. Am. Chem. Soc. 130 , 13518-13519, (2008)
Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol...