Mefexamide

Names

[ Name ]:
Mefexamide

[Synonym ]:
p-Methoxyphenoxyacetic acid 2-(diethylamino)ethylamide
p-Methoxyphenoxyacetic acid 2-[diethylamino]ethylamide
Mefexamide hydrochloride
4-Methoxy-phenoxyessigsaeure-<2-diethylamino-ethylamid>
N,N-Diethyl-N'-<(4-methoxy-phenoxy)-acetyl>-ethylendiamin
mefexamide

Biological Activity

[Description]:

Mefexamide is a particular psychostimulant.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0586 (rough estimate)

[ Boiling Point ]:
460.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₄N₂O₃

[ Molecular Weight ]:
280.36

[ Flash Point ]:
232.2ºC

[ PSA ]:
50.80000

[ LogP ]:
2.72490

[ Vapour Pressure ]:
1.17E-08mmHg at 25°C

[ Index of Refraction ]:
1.5800 (estimate)

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7175000

CHEMICAL NAME :: Acetamide, N-(2-(diethylamino)ethyl)-2-(p-methoxyphenoxy)-

CAS REGISTRY NUMBER :: 1227-61-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H24-N2-O3

MOLECULAR WEIGHT :: 280.41

WISWESSER LINE NOTATION :: 2N2&2MV1OR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMPYAT Annales Medico-Psychologiques. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-Series 11, V.2, 1843-1921; V.80- 1922- Volume(issue)/page/year: 123,141,1965

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330

[ Precautionary Statements ]:
P260-P264-P280-P284-P302 + P350-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
26/27/28

[ Safety Phrases ]:
22-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AB7175000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

[Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants].

Biull. Eksp. Biol. Med. 94(10) , 48-51, (1982)

[Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)].

Ann. Univ. Mariae Curie. Sklodowska. Med. 34 , 259-68, (1979)

[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].

Z. Rechtsmed. 87(1-2) , 117-27, (1981)

After oral administration of a therapeutic dosage (400 mg) Mefexamide (I), six excretion products were detected in human urine and subsequently identified by GC/MS and TLC: in addition to the unchange...