[D-Ala2] -Deltorphin II

Names

[ Name ]:
[D-Ala2] -Deltorphin II

[Synonym ]:
Tyr-D-Ala-Phe-Glu-Val-Val-Gly amide
M.W. 782.89 C38H54N8O10
DELTORPHIN B
DADELT II
H-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2
H2N-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2
deltorphin II
TYR-D-ALA-PHE-GLU-VAL-VAL-GLY-NH2
DELTORPHIN II
Deltorphin 2

Biological Activity

[Description]:

Deltorphin 2 is a selective peptide agonit for the δ opioid receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

Peptides

[Target]

δ opioid receptor[1]

[In Vitro]

Deltorphin 2 ([D-Ala2]-Deltorphin II) is enzymatically stable, amphibian heptapeptides that has a high affinity and selectivity for delta-opioid receptor. Deltorphin 2 is the most selective natural delta opioid receptor agonist[1].

[References]

[1]. Thomas SA, et al. Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J Pharmacol Exp Ther. 1997 May;281(2):817-25.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.272 g/cm3

[ Boiling Point ]:
1256.2ºC at 760 mmHg

[ Molecular Formula ]:
C₃₈H₅₄N₈O₁₀

[ Molecular Weight ]:
782.88300

[ Flash Point ]:
713.5ºC

[ Exact Mass ]:
782.39600

[ PSA ]:
301.24000

[ LogP ]:
2.47290

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Membrane partitioning of various delta-opioid receptor forms before and after agonist activations: the effect of cholesterol.

Biochim. Biophys. Acta 1778(6) , 1483-92, (2008)

Lipid rafts depicted as densely packed and thicker membrane microdomains, based on the dynamic clustering of cholesterol and sphingolipids, may help as platforms involved in a wide variety of cellular...

Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.

Eur. J. Neurosci. 32(11) , 1921-9, (2010)

We have shown that delta opioid receptor (DOPR)-mediated analgesia was enhanced in the complete Freund's adjuvant (CFA) model of inflammation. This effect is thought to originate from translocation of...

Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.

Pharm. Res. 26(5) , 1226-35, (2009)

To investigate whether conjunctival epithelial cells express transport processes for opioid peptides.We monitored the uptake of [(3)H]deltorphin II and [(3)H]DADLE, two hydrolysis-resistant synthetic ...