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Pirepemat

Names

[ CAS No. ]:
1227638-29-0

[ Name ]:
Pirepemat

[Synonym ]:
3-(2,3-Difluorophenyl)-3-methoxypyrrolidine
Irl-752
Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-

Biological Activity

[Description]:

Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

IRL752 displayed its highest in vitro affinities for 5-HT and NA-related targets[2].

[In Vivo]

IRL752 (3.7-100 µmol/kg, s.c.) has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reversed deficits resulting from hypomonoaminergic function[2]. Animal Model: Normal rats[2]. Dosage: 3.7-100 µmol/kg. Administration: s.c., 30 min prior to testing. Result: Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.

[References]

[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease.

[2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
276.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H13F2NO

[ Molecular Weight ]:
213.22

[ Flash Point ]:
120.8±27.3 °C

[ Exact Mass ]:
213.096527

[ LogP ]:
1.01

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.515

Related Compounds