TAMRA-PEG3-Azide

Names

[ Name ]:
TAMRA-PEG3-Azide

[Synonym ]:
2-[6-(Dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl]benzoate - N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)acetamide (1:1)
MFCD28334528

Biological Activity

[Description]:

TAMRA-PEG3-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₃₈N₆O₇

[ Molecular Weight ]:
646.733

[ Exact Mass ]:
646.311523

TAMRA-PEG3-Azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds