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Deriglidole

Names

[ CAS No. ]:
122830-14-2

[ Name ]:
Deriglidole

[Synonym ]:
(+)-1,2,4,5-Tetrahydro-2-(2-imidazolin-2-yl)-2-propylpyrrolo(3,2,1-hi)indole
UNII-68EP8R4PMV
2-(4,5-dihydro-1h-imidazol-2-yl)-2-propyl-1,2,4,5-tetrahydropyrrolo[3,2,1-hi]indole

Biological Activity

[Description]:

Deriglidole is a peripheral adrenoceptor antagonist with a high affinity for α2-adrenoceptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Metabolic Disease

[Target]

Adrenoceptor[1]


[In Vitro]

Deriglidole is a selective α2-receptor inhibitor. Deriglidole inhibits [3H]Clonidine and [3H]Idazoxan but not [3H]Prazosin binding to rat cortical and human platelet α2-adrenoceptors and is more selective than Idazoxan for peripheral receptors[1].

[References]

[1]. Natali A, et al. Effects of acute alpha 2-blockade on insulin action and secretion in humans. Am J Physiol. 1998 Jan;274(1 Pt 1):E57-64.


[Related Small Molecules]

Isoprenaline hydrochloride | ICI 118,551 (hydrochloride) | Phenylephrine hydrochloride | Yohimbine hydrochloride | Adrenaline | Ivabradine hydrochloride | Prazosin hydrochloride | Clenbuterol hydrochloride | Phentolamine mesilate | guanfacine hydrochloride | pimozide | Sotalol hydrochloride | Carvedilol | Atenolol | Metroprolol succinate

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
456.4ºC at 760mmHg

[ Molecular Formula ]:
C16H21N3

[ Molecular Weight ]:
255.35800

[ Flash Point ]:
229.8ºC

[ Exact Mass ]:
255.17400

[ PSA ]:
27.63000

[ LogP ]:
1.97520

[ Vapour Pressure ]:
1.62E-08mmHg at 25°C

[ Index of Refraction ]:
1.686

[ Storage condition ]:
2-8℃

Related Compounds