Telmesteine

Names

[ Name ]:
Telmesteine

[Synonym ]:
(R)-3-(Ethoxycarbonyl)thiazolidine-4-carboxylic acid
Telmesteinum
Telmesteine (INN)
Telmesteine
Telmesteina
(R)-thiazolidine-3,4-dicarboxylic acid-3-ethyl ester
Reolase (TN)
N-ethoxycarbonyl-D-thiazolidine-4-carboxylic acid
(R)-Thiazolidin-3,4-dicarbonsaeure-3-aethylester
Telmesteinum [INN-Latin]
UNII-124I3FE35T

Biological Activity

[Description]:

Telmesteine is an amucolitic agent. Telmesteine has anti-protease activity. Telmesteine inhibits LPS-induced NO production in RAW264.7 cells. Telmesteine can be used for research of inflammation, such as acute and chronic bronchitis and obstructive airways disease[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Lee J, et al. Absorption, distribution, metabolism and excretion of telmesteine, a mucolitic agent, in rat. Xenobiotica. 2003 Jul;33(7):755-65.

[2]. Xuetao Xu, et al. Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases. RSC Adv., 2017, 7, 34699-34704.

Chemical & Physical Properties

[ Density]:
1.409g/cm3

[ Boiling Point ]:
386.221ºC at 760 mmHg

[ Melting Point ]:
98ºC

[ Molecular Formula ]:
C₇H₁₁NO₄S

[ Molecular Weight ]:
205.23

[ Flash Point ]:
187.38ºC

[ Exact Mass ]:
205.04100

[ PSA ]:
92.14000

[ LogP ]:
0.54030

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.562

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%