microcystin LY

Names

[ Name ]:
microcystin LY

[Synonym ]:
MFCD10567358

Biological Activity

[Description]:

Microcystin-LY, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa[2], acts as an activator of the Nrf2 pathway to induce oxidative stress response, and the induction effect is most obvious at 3μM.[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Others

[Target]

Nrf2[1]

[References]

[1]. Lundqvist J, et al. Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins. Toxicon. 2017 Feb;126:47-50.

[2]. Stoner RD, et al. The effects of single L-amino acid substitutions on the lethal potencies of the microcystins. Toxicon. 1989;27(7):825-8.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
1310.2ºC at 760mmHg

[ Molecular Formula ]:
C₅₂H₇₁N₇O₁₃

[ Molecular Weight ]:
1002.16

[ Flash Point ]:
746.2ºC

[ Exact Mass ]:
1001.51000

[ PSA ]:
319.91000

[ LogP ]:
4.10640

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S16

[ RIDADR ]:
UN 1230 3/PG 2