Boc-NH-PEG11-NH2

Names

[ CAS No. ]:
1233234-77-9

[ Name ]:
Boc-NH-PEG11-NH2

[Synonym ]:
Boc-PEG-amine (n=11)
2-Methyl-2-propanyl (35-amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacont-1-yl)carbamate
MFCD03453245
Carbamic acid, N-(35-amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacont-1-yl)-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Boc-NH-PEG11-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
667.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H60N2O13

[ Molecular Weight ]:
644.792

[ Flash Point ]:
357.5±31.5 °C

[ Exact Mass ]:
644.409546

[ LogP ]:
-3.03

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.467

Related Compounds