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rac BHFF

Names

[ CAS No. ]:
123557-91-5

[ Name ]:
rac BHFF

[Synonym ]:
bhff
rac bhff

Biological Activity

[Description]:

rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice[1]. rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg−1 (P<0.001)[1]. Animal Model: Male NMRI mice (20-25 g)[1]. Dosage: 3, 10, 30 or 100 mg/kg. Administration: P.O.. Result: Significantly increased the LRR effects of a subthreshold dose of baclofen at doses of 3 mg/kg and above.

[References]

[1]. P Malherbe, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol. 2008 Jun;154(4):797-811.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H21F3O3

[ Molecular Weight ]:
330.34

[ Exact Mass ]:
330.14400

[ PSA ]:
46.53000

[ LogP ]:
3.95050

[ Storage condition ]:
-20℃

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds