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Osmundacetone

Names

[ CAS No. ]:
123694-03-1

[ Name ]:
Osmundacetone

[Synonym ]:
3,4-dihydroxybenzalacetone
4-(3,4-dihydroxyphenyl)-(E)-3-buten-2-one
4-(3,4-Dihydroxyphenyl)-3-buten-2-one
4-(3,4-dihydroxy-phenyl)-but-3-en-2-one
(3E)-4-(3,4-dihydroxyphenyl)-but-3-en-2-one
3-Buten-2-one,4-(3,4-dihydroxyphenyl)-,(3E)
MFCD00916691
4-(3,4-Dihydroxy-phenyl)-but-3-en-2-on
3-Buten-2-one,4-(3,4-dihydroxyphenyl)-,(E)
(E)-3,4-Dihydroxybenzylideneacetone
Osmundacetone

Biological Activity

[Description]:

(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Research Areas >> Neurological Disease
Signaling Pathways >> MAPK/ERK Pathway >> JNK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Tuy An Trinh, et al. Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. Biomolecules.2021 Feb 22;11(2):328.

Chemical & Physical Properties

[ Density]:
1.264g/cm3

[ Boiling Point ]:
382.5ºC at 760mmHg

[ Melting Point ]:
173-175ºC

[ Molecular Formula ]:
C10H10O3

[ Molecular Weight ]:
178.18500

[ Flash Point ]:
199.3ºC

[ Exact Mass ]:
178.06300

[ PSA ]:
57.53000

[ LogP ]:
1.70000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Methanol

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds