ω-3 Arachidonic Acid ethyl ester

Names

[ Name ]:
ω-3 Arachidonic Acid ethyl ester

[Synonym ]:
Ethyl (8Z,11Z,14Z,17Z)-8,11,14,17-icosatetraenoate
.ω.-3 Arachidonic Acid ethyl ester
8,11,14,17-Eicosatetraenoic acid, ethyl ester, (8Z,11Z,14Z,17Z)-

Biological Activity

[Description]:

omega-3 Arachidonic Acid ethyl ester is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
418.1±24.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₆O₂

[ Molecular Weight ]:
332.520

[ Flash Point ]:
100.7±21.2 °C

[ Exact Mass ]:
332.271515

[ PSA ]:
26.30000

[ LogP ]:
7.88

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.485

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3855100

CHEMICAL NAME :: 8,11,14,17-Eicosatetraenoic acid, ethyl ester, (all Z)-

CAS REGISTRY NUMBER :: 123940-93-2

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H36-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,801,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,801,1989