4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

Names

[ Name ]:
4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

[Synonym ]:
D-Alaninamide, N-(4-aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-
1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[1-[[1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
MFCD00237459
N-(4-Aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-D-alaninamide

Biological Activity

[Description]:

FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[In Vitro]

FN-439 inhibits collagenase-1 with an IC50 value of 1 μM[1]. FN-439 (1 μM) reduces the invasive potential of MDA-MB-231 breast cancer cells[1].

[In Vivo]

FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2].

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₃H₃₄N₆O₆

[ Molecular Weight ]:
490.553

[ Exact Mass ]:
490.253998

[ PSA ]:
182.96000

[ LogP ]:
-0.69

[ Index of Refraction ]:
1.583

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.

Int. J. Mol. Sci. 16 , 15659-69, (2015)

Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ...

Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids.

Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994)

Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A wat...

Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids.

Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991)

To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38...