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Oseltamivir acid D3

Names

[ CAS No. ]:
1242184-43-5

[ Name ]:
Oseltamivir acid D3

[Synonym ]:
[2H3]-Oseltamivir acid

Biological Activity

[Description]:

Oseltamivir acid D3 (GS 4071 D3) is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[References]

[1]. Li W, et al. Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother. 1998 Mar;42(3):647-53.

[2]. Ghosh GC, et al. Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan. Environ Health Perspect. 2010 Jan;118(1):103-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H21D3N2O4

[ Molecular Weight ]:
287.37000

[ Exact Mass ]:
287.19200

[ PSA ]:
105.14000

[ LogP ]:
2.34750

Related Compounds