DS-6930

DS-6930 (DS 6930, DS6930) is a novel potent, selective PPARγ agonist with EC50 of 41 nM, Emax-68%; significantly recruits several cofactors, such as RIP140 and PGC1, in cofactor recruitment assays; demonstrateshigh PPARγ agonist potency with robust plasma glucose reduction, maintains diminished PPARγ-related adverse effects upon toxicological evaluation in vivo, and demonstrated no hepatotoxicity. Diabetes Discontinued

References 1. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5099-5117. 2. Shinozuka T, et al. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. View Related Products by Target PPAR Diabetes