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Propargyl-PEG4-CH2CH2-Boc

Names

[ CAS No. ]:
1245823-50-0

[ Name ]:
Propargyl-PEG4-CH2CH2-Boc

[Synonym ]:
MFCD22201534
2-Methyl-2-propanyl 4,7,10,13,16-pentaoxanonadec-18-yn-1-oate
4,7,10,13,16-Pentaoxanonadec-18-yn-1-oic acid, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based non-cleavable ADC linker. Propargyl-PEG5-Boc can used to synthesize ADC inhibitors of Galectin-3[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
420.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H32O7

[ Molecular Weight ]:
360.443

[ Flash Point ]:
179.0±27.4 °C

[ Exact Mass ]:
360.214813

[ LogP ]:
0.53

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.456

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds