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SN-32976

Names

[ CAS No. ]:
1246202-11-8

[ Name ]:
SN-32976

[Synonym ]:
2-[(4-{4-[2-(Difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl}-1-piperazinyl)sulfonyl]-N,N-dimethylethanamine
Ethanamine, 2-[[4-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-1-piperazinyl]sulfonyl]-N,N-dimethyl-

Biological Activity

[Description]:

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.

[References]

References 1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730. View Related Products by Target PI3K

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
760.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H33F2N9O4S

[ Molecular Weight ]:
581.638

[ Flash Point ]:
413.8±35.7 °C

[ Exact Mass ]:
581.234436

[ LogP ]:
-0.20

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.672

Related Compounds