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Desmethyl VS-5584

Names

[ CAS No. ]:
1246535-95-4

[ Name ]:
Desmethyl VS-5584

[Synonym ]:
2-Pyrimidinamine, 5-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-
5-[9-Isopropyl-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine
5-(9-isopropyl-2-morpholin-4-yl-9H-purin-6-yl)-pyrimidin-2-ylamine
5-(9-isopropyl-2-morpholin-4-yl-9H-purin-6-yl)pyrimidin-2-ylamine
Desmethyl VS-5584

Biological Activity

[Description]:

Desmethyl-VS-5584 is a dimethyl analog of VS-5584 which is an potent and selective mTOR/PI3K dual inhibitor with pyrido [2,3-d] pyrimidine structure[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[References]

[1]. Hart S, Novotny-Diermayr V, Goh KC, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013;12(2):151-161.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
669.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H20N8O

[ Molecular Weight ]:
340.383

[ Flash Point ]:
358.6±34.3 °C

[ Exact Mass ]:
340.175995

[ PSA ]:
107.87000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.766

[ Storage condition ]:
-20℃

Related Compounds