Dextromethorphan

Controlled Substances

Psychoactive Drugs/Narcotic Drugs/Hypertoxic Chemicals/Non-Medical Use of Narcotic Drugs and Psychotropic Substances

Names

[ CAS No. ]:
125-71-3

[ Name ]:
Dextromethorphan

[Synonym ]:
Dexyromethorphan
Vicks 44 Cough Relief
Diabe-Tuss DM Syrup
l-Methorphan
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
Dextrometorfano [INN-Spanish]
Pertussin CS Children's Strength
Robitussin Pediatric Cough Suppressant
Morphinan, 3-methoxy-17-methyl-, (9-α,13-α,14-α)- (9CI)
Trocal
Creo-Terpin
Novahistine DM
(9α,13α,14α)-3-Methoxy-17-methylmorphinan
EINECS 204-752-2
Robitussin Maximum Strength Cough Suppressant
Novahistex DM
(+)-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthren
4-21-00-01367 (Beilstein Handbook Reference)
Cough-X
Delsym Cough Formula
Dormetan
d-Methorphan
(9a,13a,14a)-3-Methoxy-17-methylmorphinan
Dextromethorphan (USP)
Sucrets 4 Hour Cough Suppressant
Dextrometorphan
Demorphine
Hold DM
Triaminic DM Long Lasting for Children
Robitussin Pediatric
Balminil DM
[14C]-Dextromethorphan
[3H]-Dextromethorphan
Benylin Pediatric Cough Suppressant
3-Methoxy-17-methyl-9a,13a,14a-morphinan
Pertussin DM Extra Strength
Koffex DM
(9α,13α,14α)-17-methyl-3-(methyloxy)morphinan
Calmylin #1
dextromethorpan
Dextromethorfan [Czech]
Delsym
MFCD00866833
4-21-00-01367
Destrometerfano [DCIT]
(+)-3-Methoxy-N-methylmorphinon
Dextromorphan

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
394.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₅NO

[ Molecular Weight ]:
271.397

[ Flash Point ]:
116.2±30.2 °C

[ Exact Mass ]:
271.193604

[ PSA ]:
12.47000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.585

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD0194000

CHEMICAL NAME :: 9-alpha,13-alpha,14-alpha-Morphinan, 3-methoxy-17-methyl-

CAS REGISTRY NUMBER :: 125-71-3

BEILSTEIN REFERENCE NO. :: 0088549

LAST UPDATED :: 199803

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H25-N-O

MOLECULAR WEIGHT :: 271.44

WISWESSER LINE NOTATION :: T6 G666/FQ 2AF Q FX OM&TTTJ IO1 O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 7,163,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,1188,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16286 ug/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,1188,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1523,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4165 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 3059 (estimated) No. of Female Employees: 1803 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
16-36/37-45

[ RIDADR ]:
3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)