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m-PEG-acid

Names

[ CAS No. ]:
125220-94-2

[ Name ]:
m-PEG-acid

[Synonym ]:
MFCD08274611
2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaoctatriacontan-38-oic acid

Biological Activity

[Description]:

m-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
628.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
(C2H4O)nC4H8O3

[ Molecular Weight ]:
588.683

[ Flash Point ]:
189.3±25.0 °C

[ Exact Mass ]:
588.335693

[ LogP ]:
-4.22

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.461

Related Compounds