2-Amino-3’-deoxy-3’-fluoroadenosine

Names

[ CAS No. ]:
125391-75-5

[ Name ]:
2-Amino-3’-deoxy-3’-fluoroadenosine

[Synonym ]:
Adenosine,2-amino-3'-deoxy-3'-fluoro-(9CI)
3'F-2-NH2-3'dA
3'-Fluoro-3'-deoxy-2-aminoadenosine
Adenosine,2-amino-3'-deoxy-3'-fluoro

Biological Activity

[Description]:

2-Amino-3’-deoxy-3’-fluoroadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.17g/cm3

[ Boiling Point ]:
748.9ºC at 760 mmHg

[ Molecular Formula ]:
C10H13FN6O3

[ Molecular Weight ]:
284.25

[ Flash Point ]:
406.7ºC

[ Exact Mass ]:
284.10300

[ PSA ]:
146.06000

[ Vapour Pressure ]:
1.47E-23mmHg at 25°C

[ Index of Refraction ]:
1.903

Related Compounds