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m-PEG6-Br

Names

[ CAS No. ]:
125562-29-0

[ Name ]:
m-PEG6-Br

[Synonym ]:
2,5,8,11,14,17-Hexaoxanonadecane, 19-bromo-
19-Bromo-2,5,8,11,14,17-hexaoxanonadecane

Biological Activity

[Description]:

m-PEG6-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Jennifer Riggs-Sauthier, et al. Oligomer-antihistamine conjugates. WO2008112257A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
385.1±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H27BrO6

[ Molecular Weight ]:
359.254

[ Flash Point ]:
158.2±25.0 °C

[ Exact Mass ]:
358.099091

[ LogP ]:
-0.89

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.459

[ Storage condition ]:
-20°C

Related Compounds