Methyl-PEG9-bromide

Names

[ Name ]:
Methyl-PEG9-bromide

[Synonym ]:
28-Bromo-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosane, 28-bromo-
MFCD28950767

Biological Activity

[Description]:

m-PEG9-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.0 g/cm3

[ Boiling Point ]:
498.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₉BrO₉

[ Molecular Weight ]:
491.412

[ Flash Point ]:
208.4±0.0 °C

[ Exact Mass ]:
490.177734

[ LogP ]:
-0.88

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.462

Methyl-PEG9-bromide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds