DBCO-Amine

Names

[ CAS No. ]:
1255942-06-3

[ Name ]:
DBCO-Amine

[Synonym ]:
Dibenzocyclooctyne-amine
DBCO-NH2
DBCO-amine
ADIBO-AMINE

Biological Activity

[Description]:

DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Ermira Pazolli, et al. Splicing modulator antibody-drug conjugates and methods of use. WO2019232449A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₆N₂O

[ Molecular Weight ]:
276.33200

[ Exact Mass ]:
276.12600

[ PSA ]:
46.33000

[ LogP ]:
3.04710

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.

J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010)

Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react...

Copper-free click chemistry for dynamic in vivo imaging.

Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007)

Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids...

Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

Angew. Chem. Int. Ed. Engl. 47 , 2253-2255, (2008)