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CHR-3996

Names

[ CAS No. ]:
1256448-47-1

[ Name ]:
CHR-3996

Biological Activity

[Description]:

Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

IC50：8 nM ( HDAC)[1]

[References]

[1]. Moffat D, et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J Med Chem. 2010 Dec 23;53(24):8663-78.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₉FN₆O₂

[ Molecular Weight ]:
394.40

Related Compounds