Azido-PEG4-C2-acid

Names

[ Name ]:
Azido-PEG4-C2-acid

[Synonym ]:
AmbotzPEG2345
15-AZIDO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID
Azido-PEG4-acid

Biological Activity

[Description]:

Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₁N₃O₆

[ Molecular Weight ]:
291.30100

[ Exact Mass ]:
291.14300

[ PSA ]:
123.97000

[ LogP ]:
0.29056

Azido-PEG4-C2-acid

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Related Compounds