HG-7-85-01-NH2

Names

[ Name ]:
HG-7-85-01-NH2

Biological Activity

[Description]:

HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 value of 0.3 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₇F₃N₆OS

[ Molecular Weight ]:
540.60

HG-7-85-01-NH2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds