Benzyl-PEG2-azide

Names

[ Name ]:
Benzyl-PEG2-azide

[Synonym ]:
{[2-(2-Azidoethoxy)ethoxy]methyl}benzene
MFCD28064332
Benzene, [[2-(2-azidoethoxy)ethoxy]methyl]-
Benzyl-PEG2-azide

Biological Activity

[Description]:

Benzyl-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Steinebach C, et al. A MedChem toolbox for cereblon-directed PROTACs. Medchemcomm. 2019 May 28;10(6):1037-1041.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₃O₂

[ Molecular Weight ]:
221.256

[ Exact Mass ]:
221.116425

[ LogP ]:
1.90

Benzyl-PEG2-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds