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Bromoacetamido-PEG4-NHS ester

Names

[ CAS No. ]:
1260139-70-5

[ Name ]:
Bromoacetamido-PEG4-NHS ester

[Synonym ]:
MFCD20229159
2-Bromo-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}acetamide
Acetamide, 2-bromo-N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-

Biological Activity

[Description]:

Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C17H27BrN2O9

[ Molecular Weight ]:
483.308

[ Exact Mass ]:
482.089996

[ LogP ]:
-2.83

[ Index of Refraction ]:
1.528

Related Compounds