TAS-116

TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.

Research Areas >> Cancer

HSP90α:34.7 nM (Ki)

HSP90β:21.3 nM (Ki)

[1]. Kitade, Makoto; Ohkubo, Shuichi; Yoshimura, Chihoko; et al. Preparation of azabicyclo compounds and salts thereof as inhibitors of heat-shock proteins HSP 90. PCT Int. Appl. (2011), WO 2011004610 A1 20110113.

[2]. Ohkubo S, et al.TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. Mol Cancer Ther. 2015 Jan; 14(1):14-22.

17-AAG | Ganetespib(STA-9090) | NVP-AUY922 | Geldanamycin | VER-155008 | AT13387 | 17-DMAG (Alvespimycin) HCl | BIIB021 | Apoptozole | IPI-504 | KNK437 | Teprenone | KRIBB11 | Debio-0932 | HSP-990