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coumarin-SAHA

Names

[ CAS No. ]:
1260635-77-5

[ Name ]:
coumarin-SAHA

[Synonym ]:
N-Hydroxy-N'-(4-methyl-2-oxo-2H-chromen-7-yl)octanediamide
Octanediamide, N-hydroxy-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
Coumarin Suberoylanilide Hydroxamic Acid
Coumarin-SAHA

Biological Activity

[Description]:

Coumarin-SAHA is a fluorescent probe for determining the binding affinities (kd) and the dissociation off-rates (koff) of the HDAC8-inhibitor complexes[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[References]

[1]. Raushan K Singh, et al. Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors. Anal Biochem

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C18H22N2O5

[ Molecular Weight ]:
346.378

[ Exact Mass ]:
346.152863

[ PSA ]:
108.64000

[ LogP ]:
1.41

[ Index of Refraction ]:
1.593

[ Storage condition ]:
-20°C

Related Compounds