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NMS-P515

Names

[ CAS No. ]:
1262395-13-0

[ Name ]:
NMS-P515

Biological Activity

[Description]:

NMS-P515 is a potent and stereospecific PARP-1 inhibitor, with an IC50 of 27 nM in hela cells. Anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PARP-1:27 nM (IC50, in hela cells)

[References]

[1]. Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10(4):534-538.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₉N₃O₂

[ Molecular Weight ]:
355.47

Related Compounds