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Xanthine-13C,15N2

Names

[ CAS No. ]:
1262670-81-4

[ Name ]:
Xanthine-13C,15N2

[Synonym ]:
(2-13C,1,3-15N2)-3,9-Dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione-2-13C-1,3-15N2, 3,9-dihydro-
Xanthic oxide-13C15N2
1H-Purine-2,6-diol

Biological Activity

[Description]:

Xanthine-13C,15N2 is a 15N-labeled and 13C-labled Deruxtecan. Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and amaleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-244.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-244.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C413CH4N215N2O2

[ Molecular Weight ]:
155.09

[ Exact Mass ]:
155.030853

[ Index of Refraction ]:
1.636

Related Compounds