Clothianidine-d3

Names

[ Name ]:
Clothianidine-d3

[Synonym ]:
1-[(2-chlorothiazol-5-yl)methyl]-2-nitro-3-(trideuteriomethyl)guanidine
1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-(H)methyl-3-nitroguanidine
Clothianidin-d3
Clothianidine-d3
(E)-1-(2-Chloro-5-thiazolylmethyl)-3-(methyl-d3)-2-nitroguanidine
Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N'-methyl-d-N''-nitro-

Biological Activity

[Description]:

Clothianidin-d3 is the deuterium labeled Clothianidin.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
435.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₅ClD₃N₅O₂S

[ Molecular Weight ]:
252.697

[ Flash Point ]:
217.0±31.5 °C

[ Exact Mass ]:
252.027557

[ PSA ]:
123.37000

[ LogP ]:
-0.15

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.709

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.

PLoS ONE 11 , e0146335, (2016)

Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha...

Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario.

Environ. Toxicol. Chem. 35 , 295-302, (2016)

Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration...