endo-BCN-PEG2-NH2

Names

[ CAS No. ]:
1263166-93-3

[ Name ]:
endo-BCN-PEG2-NH2

[Synonym ]:
MFCD19705418

Biological Activity

[Description]:

endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₈N₂O₄

[ Molecular Weight ]:
324.41500

[ Exact Mass ]:
324.20500

[ PSA ]:
82.81000

[ LogP ]:
2.23530

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.

Angew. Chem. Int. Ed. Engl. 49 , 9422-9425, (2010)