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m-PEG2-O-Ph-3-NH2

Names

[ CAS No. ]:
126415-02-9

[ Name ]:
m-PEG2-O-Ph-3-NH2

[Synonym ]:
Benzenamine, 3-[2-(2-methoxyethoxy)ethoxy]-
MFCD11652541
3-[2-(2-Methoxyethoxy)ethoxy]aniline

Biological Activity

[Description]:

m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
346.2±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H17NO3

[ Molecular Weight ]:
211.258

[ Flash Point ]:
173.9±17.4 °C

[ Exact Mass ]:
211.120850

[ LogP ]:
0.14

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.521

Related Compounds