2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine

Names

[ Name ]:
2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine

[Synonym ]:
(2r,3r,4s,5r)-4-fluoro-2-(hydroxymethyl)-5-(6-(methylamino)-9h-purin-9-yl)tetrahydrofuran-3-ol

Biological Activity

[Description]:

2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₄FN₅O₃

[ Molecular Weight ]:
283.26

[ Exact Mass ]:
283.10800

[ PSA ]:
105.32000