OTs-C6-OBn

Names

[ CAS No. ]:
126519-80-0

[ Name ]:
OTs-C6-OBn

[Synonym ]:
6-benzyloxy-1-hexyl 4-toluenesulfonate
6-benzyloxyhexyl tosylate
6-benzyloxyhexyl 4-methylbenzenesulfonate

Biological Activity

[Description]:

OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H26O4S

[ Molecular Weight ]:
380.49800

[ Exact Mass ]:
380.16600

[ PSA ]:
92.21000

[ LogP ]:
5.07840

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds