GR 89696 free base

Names

[ CAS No. ]:
126766-31-2

[ Name ]:
GR 89696 free base

Biological Activity

[Description]:

GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

[In Vivo]

GR 89696 free base (肌内注射, 0.01-0.1 μg/kg) 剂量依赖性减弱鞘内注射吗啡 (0.03 mg) 诱导的抓挠反应而不影响吗啡的镇痛作用[1]。 GR-896960 free base (皮下注射，1 mg/kg) 在永久性局灶性缺血大鼠模型中将脑动脉梗塞体积减少 38%[2]。

[References]

[1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200.   

[2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H25Cl2N3O3

[ Molecular Weight ]:
414.33

Related Compounds