5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone

Names

[ Name ]:
5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone

[Synonym ]:
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-, (2S)-
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one
(2S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-

Biological Activity

[Description]:

5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone (compound 1), a flavonoid, is a potent ABCG2 inhibitor with an IC50 of 6.6 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP

[References]

[1]. Muhammad Ali Versiani, et al. Flavonoids from Eight Tropical Plant Species That Inhibit the Multidrug Resistance Transporter ABCG2. J Nat Prod. 2011 Feb 25;74(2):262-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
616.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₆

[ Molecular Weight ]:
370.396

[ Flash Point ]:
219.1±25.0 °C

[ Exact Mass ]:
370.141632

[ PSA ]:
96.22000

[ LogP ]:
4.99

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%