SOMG-833
Names
[ CAS No. ]:
1268264-10-3
[ Name ]:
SOMG-833
Biological Activity
[Description]:
A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.
[References]
References 1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45. View Related Products by Target c-Met (HGFR)
Chemical & Physical Properties
[ Molecular Formula ]:
C22H22F3N5O2
[ Molecular Weight ]:
445.446