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HDAC-IN-55

Names

[ CAS No. ]:
1268674-16-3

[ Name ]:
HDAC-IN-55

Biological Activity

[Description]:

HDAC-IN-55(8j) is a small molecular compound that can increase the expression of E-cadherin and inhibit the proliferation of cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

HDAC-IN-55(8j) 作用于SW620 细胞系和 H520 细胞系的 EC50 值分别是 4.47 和 1.61 μM[1]。 HDAC-IN-55(8j) (10 μM, 24 h) 可以使 SW620 细胞中的 E-钙粘蛋白表达增加,并抑制 SW620 细胞增殖[1]。

[References]

[1]. Sydney L Stoops, et al. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol. 2011 May 20;6(5):452-65.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17N3O3

[ Molecular Weight ]:
311.34


Related Compounds