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MK 1903

Names

[ CAS No. ]:
1268882-43-4

[ Name ]:
MK 1903

[Synonym ]:
1H-Cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid, 4,4a,5,5a-tetrahydro-, (4aR,5aR)-
mk-1903
MFCD11973801
MFCD27991272
(4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid

Biological Activity

[Description]:

MK-1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Boatman PD, et al. (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J Med Chem. 2012 Apr 26;55(8):3644-66.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
438.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H8N2O2

[ Molecular Weight ]:
164.161

[ Flash Point ]:
218.7±28.7 °C

[ Exact Mass ]:
164.058578

[ LogP ]:
0.77

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.732

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
Soluble in DMSO > 10 mM

Related Compounds