sulfamerazine sodium

Names

[ CAS No. ]:
127-58-2

[ Name ]:
sulfamerazine sodium

[Synonym ]:
EINECS 204-851-0
Sulfamerazin natrium
Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, sodium salt (1:1)
MFCD00068332
Sodium [(4-aminophenyl)sulfonyl](4-methyl-2-pyrimidinyl)azanide
2-Sulfanilamido-4-methylpyrimidine sodium salt
Solumedine
UNII-JOV4UJY07O
Solfamerazina sodica [DCIT]
Sodium sulfamerazine
sulfamerazine sodium
Soluble sulfamerazine
Sodium sulphamerazine
Sodium [(4-aminophenyl)sulfonyl](4-methylpyrimidin-2-yl)azanide
Sulfamerazine sodium salt
Sulfamerazine (sodium salt)

Biological Activity

[Description]:

Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
519.1ºC at 760mmHg

[ Melting Point ]:
216-219 °C

[ Molecular Formula ]:
C₁₁H₁₁N₄NaO₂S

[ Molecular Weight ]:
286.285

[ Flash Point ]:
267.8ºC

[ Exact Mass ]:
286.050049

[ PSA ]:
97.56000

[ LogP ]:
2.68880

[ Vapour Pressure ]:
7.03E-11mmHg at 25°C

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0760000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-, monosodium salt

CAS REGISTRY NUMBER :: 127-58-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H11-N4-O2-S.Na

MOLECULAR WEIGHT :: 286.31

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& D1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1522 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1739 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H332

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/22

[ Safety Phrases ]:
S7-S24-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3