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NSI-189

Names

[ CAS No. ]:
1270138-40-3

[ Name ]:
NSI-189

[Synonym ]:
(4-Benzyl-1-piperazinyl){2-[(3-methylbutyl)amino]-3-pyridinyl}methanone
Methanone, [2-[(3-methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]-
unii-yve9u408zl
UNII:YVE9U408ZL
NSI-189
NSI189

Biological Activity

[Description]:

NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [1] [2].in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20% [3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. http://gizmodo.com/5874433/the-pill-that-could-cure-depression-by-growing-your-brain

[2]. Compositions to effect neuronal growth US 8030492 B2

[3]. Why Neuralstem Could Provide A 10x Return


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
534.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H30N4O

[ Molecular Weight ]:
366.500

[ Flash Point ]:
277.2±30.1 °C

[ Exact Mass ]:
366.241974

[ PSA ]:
48.47000

[ LogP ]:
4.13

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.601

[ Storage condition ]:
-20℃

Related Compounds