BRL 37344, sodium salt

Names

[ Name ]:
BRL 37344, sodium salt

[Synonym ]:
sodium,2-[4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetate

Biological Activity

[Description]:

BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Metabolic Disease

[Target]

β3-adrenergic receptor[1]

[In Vivo]

BRL37344 sodium (BRL 37344A) treatment significantly lowers the body weight of obese mice[1]. Animal Model: Five-week-old male Imprinting Control Region (ICR) mice[1] Dosage: 2.5 mg/kg Administration: Intraperitoneal injection; three times per week for two weeks Result: Lowered the body weight of obese mice.

[References]

[1]. Wu C, et al. Activating brown adipose tissue for weight loss and lowering of blood glucose levels: a microPET study using obese and diabetic model mice. PLoS One. 2014 Dec 2;9(12):e113742.

Chemical & Physical Properties

[ Boiling Point ]:
569.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₁ClNNaO₄

[ Molecular Weight ]:
385.81700

[ Flash Point ]:
298.4ºC

[ Exact Mass ]:
385.10600

[ PSA ]:
81.62000

[ LogP ]:
2.11380

[ Vapour Pressure ]:
8.09E-14mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25