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Y-26763

Names

[ CAS No. ]:
127408-31-5

[ Name ]:
Y-26763

[Synonym ]:
hms3268j05

Biological Activity

[Description]:

Y-26763 is a K+ channel opener and active metabolite of Y-27152[1]. Y-26763 is an ATP-sensitive K+ (KATP) channel activator[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Itoh T, et al. Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery. Br J Pharmacol. 1994 Jan;111(1):165-72.

[2]. Tran QTN, et al. The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent. Eur J Med Chem. 2019 Jul 15;174:33-44.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
455.4ºC at 760mmHg

[ Molecular Formula ]:
C14H16N2O4

[ Molecular Weight ]:
276.29

[ Flash Point ]:
229.2ºC

[ Exact Mass ]:
276.11100

[ PSA ]:
93.79000

[ LogP ]:
1.36898

[ Vapour Pressure ]:
4.4E-09mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
2-8℃

Related Compounds