Amino-PEG2-NH-Boc

Names

[ Name ]:
Amino-PEG2-NH-Boc

[Synonym ]:
AmbotzPEG1067
1-t-butoxycarbonylamino-3-oxa-pentan-5-amine
N-Boc-2-(2-amino-ethoxy)-ethylamine
tert-butyl 2-(2-aminoethoxy)ethylcarbamate
N-(tert-butyloxycarbonyl)-2,2'-oxybis(ethylamine)
5-(tert-butyloxycarbonylamino)-3-oxa-pentyl amine
N-t-butoxycarbonyl-3-oxa-1,5-pentanediamine
tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate
BOCNH-PEG1-CH2CH2NH2

Biological Activity

[Description]:

Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Qiu X, et al. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019 May 17;21(10):3838-3841.

Chemical & Physical Properties

[ Density]:
1.024g/cm3

[ Boiling Point ]:
321.128ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₂₀N₂O₃

[ Molecular Weight ]:
204.26700

[ Flash Point ]:
148.013ºC

[ Exact Mass ]:
204.14700

[ PSA ]:
77.07000

[ LogP ]:
1.39110

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.457

[ Water Solubility ]:
Soluble (53 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%