PI3K-IN-8q
Names
[ CAS No. ]:
1280204-67-2
[ Name ]:
PI3K-IN-8q
Biological Activity
[Description]:
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable.
[References]
References 1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543. View Related Products by Target PI3K
Chemical & Physical Properties
[ Molecular Formula ]:
C23H23FN8O
[ Molecular Weight ]:
446.49