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1-Cbz-3-Hydroxyazetidine

Names

[ CAS No. ]:
128117-22-6

[ Name ]:
1-Cbz-3-Hydroxyazetidine

[Synonym ]:
1-Cbz-3-Hydroxyazetidine
1-Azetidinecarboxylic acid,3-hydroxy-,phenylmethyl ester
1-Azetidinecarboxylic acid, 3-hydroxy-, phenylmethyl ester

Biological Activity

[Description]:

1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
356.7±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H13NO3

[ Molecular Weight ]:
207.226

[ Flash Point ]:
169.5±27.9 °C

[ Exact Mass ]:
207.089539

[ PSA ]:
49.77000

[ LogP ]:
0.45

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.608

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds